Level 2 Paediatric Emergency First Aid

CU1514 Paediatric Emergency First Aid 20 pages 1. 1 Identify the responsibilities of a paediatric first aider. I should aim to preserve life, prevent the condition worsening, and promote recovery. Responsibility Description -Remain calm at all timesAppear confident and reassuring -Conduct a scene surveyAssess the situation without Endangering my own life. -Conduct a primary surveyIdentify and assess the extent of the Illness, injury or condition of the casualty. Attend to the needs of otherEnsure their safety and manage children or bystandersbehaviour. -Send for medical helpAmbulance, police or emergency rescue services (as a first aider, I should always stay with the casualty and send someone else to call for help if possible) -Give immediate, appropriate treatmentto preserve life, prevent the condition worsening and promote recovery -Take appropriate precautions to minimise infection Protect yourself and casualty by using appropriate techniques and equipment Arrange for further, qu alified medical attention Transporting the casualty to hospital or arranging for medical examination. -Reporting and recordingVerbal and written records, completing accident and incident reports -Maintaining first aid equipment, including first aid kits Ensure equipment is up-to-date and first aid kits are well stocked -Keeping up-to-date with first aid procedures Take part in regular updating and training 1. 2 Describe how to minimise the risk of infection to self and others.I should do the following to minimise the risk of infection to self and others:- * I should always wash my hands before and after giving first aid treatment * I should always wear disposable gloves for dealing with any first aid situations involving blood or other body fluids (e. g. vomit) * Cover the casualty’s open wounds with appropriate sterile dressings * Make sure my own cuts or sores are adequately covered by plasters * Use appropriate protective equipment where my own safety may be put at risk, e . g. face shields * Dispose of any soiled dressings (e. g. lood soaked), or other first aid materials, in appropriate clinical waste disposal bags. 1. 3 Describe suitable first aid equipment, including personal protections, and how it is used appropriately. First aid equipment usually consists of collection of supplies for administering first aid, minimising the risk of infection and personal protective equipment (PPE). A first aid kit must be easily identifiable and clearly labelled, usually with a white cross on a green background. It is important that first aid equipment is easily accessible and not locked away, it should be clearly signed.The first aid box should be checked regularly to make sure that nothing is damaged and nothing is missing. The contents of a first aid kit may vary slightly depending on the policies and procedures of the setting. Some settings do not use plasters or cleansing wipes because of allergy risks for children. General first and kits should never cont ain medicines of any kind, even basic painkillers. First aiders are not qualified to give medicines to children as they do not know the medical history or any allergies the child may have. A standard first aid kit will usually contain the following: * Sterile dressings of different sizes (e. . sterile gauze pads, eye pads) * Bandages of different types and sizes (e. g. triangular, roller, finger bandages) * Adhesive tape (non-allergenic) * Disposable gloves * Scissors * Tweezers * Safety pins * Disposable face shields * Disposable thermometers 1. 4 Identify what information needs to be included in an accident report/incident record, and how to record it. It is important that all settings complete a specific from to accidents and incidents, these forms are completed for this purpose. * It is a legal requirement * It provides a record in the event of complications (e. . following a head injury). * It informs parents and carers. * It can help to monitor potential hazards in the setting . * It may be required as evidence in suspected cases of abuse of non-accidental injuries. Information should always be recorded clearly and accurately and should be signed and dated by the first aider. Some accident report forms use body diagrams to help in the descriptions of specific injuries, for example, showing exactly where bruising appeared or the particular area where a child feels pain. The main information recorded should include:- Details of the injured or sick child (name, date of birth, main contact details) – Details of the accident or incident (date, time, where it happened) – Details of action of treatment given (what happened, extent of any injuries, treatment given) – Advice of further treatment recommended (e. g. hospital treatment) – Information parents and carers (when and how parents have been contacted) – Signature of the first aider, the date and time. – Information should be written in black pen. 1. 5 Define an infa nt and child for the purposes of first aid treatment.An infant is usually defined as under the age of one year and child from one year to approximately 12 years old. However, some first aid treatment will vary depending on size and weight of casualty and techniques should always be adapted accordingly. 2. 1 Demonstrate how to conduct a scene survey A scene survey involves your initial assessment of the emergency situation and deciding on the priorities of your action. Use your senses to assess what might have happened: * Look for clues (e. g. an empty medicine bottle beside an unconscious child). * Listen to information form others (e. g. ther children telling you what happened). * Smell anything unusual (e. g. gas or other fumes) When conducting a scene survey, you must consider: * Whether I or the casualty are in any danger (e. g. if the building is on fire) * If the casualty has any lie-threatening conditions (e. g. not breathing) * If any bystanders can help you (e. g. other chi ldren or colleagues) * Whether you need to call for further assistance (e. g. ambulance, police or rescue services). Conducting a scene survey helps the first aider to assess the seriousness of the situation and decide on the priorities for action.It also assist in deciding what further help, if any, is required, If there is more than one casualty, then the first aider needs to prioritise treatment, deal with the most serous first and remember that the quietest casualty often needs the most help. In calling for help, the first aider must decide what help is required and how to send for help, some situations may involve sending for emergency services such as ambulance, police or fire and rescue. Other situations may need the assistance of another adult, a colleague, manager or supervisor. 2. 2 Demonstrate how to conduct a primary survey on an infant and child.Once I have conducted a scene survey and decided on your priorities, then a primary survey will provide a more detailed assess ment of the casualty. To do this you must consider DRABC. * DANGER -If you have not already done so, make sure the casualty is safe. * RESPONSE – Ask the casualty ‘Can you hear me? ’ or ‘what happened? ’ If they respond, then you know that they are conscious and breathing and I should remain calm, reassure the casualty and continue with my examination If there is no response, then I should send for help and proceed as follows: * AIRWAY – Open the airway by gently tilting the head back and lifting the chin.This will prevent the casualty’s tongue from blocking their airway. * BREATHING – Look to see if the chest is rising and falling, listen for breathing sounds and place your cheek close to the casualty’s nose and mouth to feel for breath. If the casualty is breathing normally, place them in the recovery position, unless you suspect a spinal injury and continue with your examination. If the casualty is not breathing, then g ive five rescue breaths and prepare to begin CPR * CIRCULATION – Check the casualty’s pulse by feeling the major artery in the neck, (carotid artery) just below the jaw line. . 3 Identify when and how to call for help. The trained first aider should always stay with the casualty and send someone else to call to help. This allows for first aider to monitor the condition of the casualty and perform any treatment if required, for example carrying out CPR if the casualty stops breathing. Never leave an infant or child casualty unattended. If any of the emergency services are required, this should be done by telephoning, 999.It is essential o communicate the following information accurately * Which emergency service is required ( ambulance, police and/or fire and rescue service) * A contact telephone number (usually the number the call is made from) * The exact location of the incident(Local landmarks provide a useful guide) * The type and seriousness of the incident (e. g. road traffic accident, school bus collided with two other vehicles, blocking a major road junction) * The number and approximate age of casualties involved (e. g. five children and one adult injured, two children in a serious condition).Once you have dealt with the priorities, you should now conduct a more detailed examination of the casualty. This will include any information from the casualty and the signs and symptoms. If the child is old enough, ask them what happened, how they fell and where they hurt. Other children or bystanders may also be able to give you information too. You should always deal with life-threatening signs and symptoms first. For example, obvious and severe bleeding. A general examination should begin at the casualty’s head and work down the body. Remember to move the casualty’s head and work down the body.Remember to move the casualty as little as possible and use your senses to look, feel, listen and smell. Use both hands to compare any diff erences between the two sides of the body. Reassure infants and young children with soothing words and a gentle touch. Signs to look for on examination of casualty Area to examinewhat to look for HEADAny bleeding, bruising or swelling (could indicator a fractured skull) FACEColour of the skin, e. g. pale, blueness (could indicate shock) EYESUnequal pupil size, blood shot eyes MOUTHAny bleeding, vomit, blueness of the lips (could indicate poisoning) flushed, sweating, clammy.EARS AND NOSEAny bleeding (could indicate a fractured skull) WHOLE BODY, NECK, ARMS AND LEGS. Any bleeding, swelling, bruising or deformity (could indicate a fracture) 3. 1 Demonstrate how to place an infant and a child into the appropriate recovery position. The recovery position is very important in first aid. It places the casualty in a stable position and ensures that an open airway is maintained. The main advantages of the recovery position are: * It prevents the tongue from falling back into the throat and blocking the airway and so maintains an open airway. Vomit or other fluid can drain easily from the casualty’s mouth, preventing choking. * It keeps the casualty in a safe and comfortable position. Recovery position for infants and children. For an infant less than a year old, a modified recovery position must be adopted: * Cradle the infant in you arms, with their head tilted downwards to prevent chocking on the tongue or inhaling vomit. * Monitor the infant’s breathing and pulse continuously. For a child over the age of one year, follow these instructions: * Turn the child onto their side. Lift the chin forward into the open airway position and adjust the child’s hand under the cheek as necessary * Check that the child cannot roll forwards or backwards * Monitor the child’s breathing and pulse continuously. If you suspect spinal injury, use the jaw thrust technique. Place your hands on either side of the child’s face. With your fingertips gently lift the jaw to open the airway and take care not to tilt the casualty’s neck. 3. 2 Describe how to continually assess and monitor an infant and a child whilst in your care. If an infant or child is unresponsive but breathing normally.It is essential to assess and monitor their condition while I wait for the ambulance to arrive What to check How to assess and what to note AirwayMake sure nothing is blocking the airway or obstructing breathing (e. g. vomit) BreathingNote the rate and depth of breathing and any changes (if the casualty stops breathing, be prepared to start CPR). Circulation Check the pulse at the neck (carotid pulse). Note the rate and strength of the pulse and any changes. ResponsivenessKeep talking and asking questions, gentle shaking or pinching the skin to see if there is any response.Note any changes. Changes in general condition Check the colour of skin and lips. Note any blueness or other changes. Check for the presence of any bleeding or complaints of p ain from the casualty. 4. 1 Identify when to administer CPR to a responsive infant and an unresponsive child who is not breathing normally. As a trained first aider, CPR should always be carried out if a casualty is unresponsive, is not breathing and has no pulse. The procedure should be followed even if you have doubts about its success and you should always carry on until help arrives.If possible, send someone else to call for an ambulance immediately, but if you are on your own, carry out CPR for one minute before calling. If there is any evidence of blood or other fluid around the child’s mouth, then a disposable face shield should be used. 4. 2 Demonstrate how to administer CPR using an infant and child manikin. CPR Procedure for infants and children. CPR for infants (less than I year old) 1. Give five rescue breaths: * Tilt the head back and lift the chin to open the airway * Seal your lips around the baby’s mouth and nose * Blow gently into the lungs, looking al ong the chest as you breathe.Fill your cheeks with air and use this amount each time. * As the chest rises, stop blowing and allow it to fall. Repeat four more times. 2. Give 30 chest compressions: * Place the baby on a firm surface. * Locate a position in the centre of the chest. * Using two fingers, press down sharply to a third of the depth of chest. * Press 30 times, at a rate of 100 compressions per minute * After 30 compressions, give two rescue breaths. 3. Continue to resuscitate at 30 compressions to two breaths until help arrives. CPR FOR CHILDREN (1-12 years old) 1. Give five rescue breaths: Tilt the head back and lift the chin to open the airway. * Seal our lips around the child’s mouth and pinch the nose. * Blow gently and watch the chest as you breathe. Make sure your breathing is shallow and do not empty your lungs completely. * As the chest rises, stop blowing and allow it to fall. * Repeat four more times, then check the child’s carotid pulse. 2. Give 3 0 chest compressions: * Place one or two hands in the centre of the chest (depending on the size of the child). * Use the heel of the hand with arms straight and press down to a third of the depth of chest. Press 30 times, at a rate of 100 compressions per minute. * After 30 compressions, give tow rescue breaths. 3. Continue to resuscitate at 30 compressions to two rescue breaths until help arrives or the child recovers. 4. 3 Describe how to deal with an infant and a child who is experiencing a seizure A seizure (also known as a convulsion or fit) consists of involuntary contractions of muscles in body. The condition is due to a disturbance in the electrical activity of the brain and seizures usually result in loss of impairment of consciousness, the most common causes are epilepsy or head injuries.General signs of a seizure are: * Sudden unconsciousness * Rigidity and arching of the back * Convulsive, jerky movements In dealing with seizures, first aid treatment must always include maintaining an open airway and monitoring the infant or child’s vital signs (their level of response, pulse and breathing). You will also need to protect the infant or child from further harm during a seizure and arrange appropriate aftercare once they have recovered. First aid treatment for a seizure includes: * If you see the child falling, try to ease the fall. If possible, protect the infant or child’s head by placing soft padding underneath it. * Make space around them and if necessary, make sure other children move away. * Remove dangerous items, such as hot drinks or sharp objects. * Note the time when the seizure started. * Loosen clothing around the infant or child’s neck. When the seizure has finished: * Open the airway and check the infant or child’s breathing Be prepared to give CPR if necessary * Place the infant or child into the recovery position they are unconscious but breathing normally. Monitor and record vital signs) level of response , pulse and breathing). * Make a note of how long the seizure lasted Do not move the infant or child unless they are in immediate danger Do not put anything in their mouth or use force to restrain them. If any of the following apply, dial 999 for an ambulance: * The infant or child is unconscious for more than 10 min * The seizure continues for more then 5 minutes * The infant or child is having repeated seizures or having a seizure for the first time. 5. 1 Differentiate between a mild and a severe airway obstruction. INFANT Mild ObstructionCheck the infant’s mouth remove any obvious obstructions. Do not sweep your finger around in the mouth (this could push any obstruction further down the airway). Severe obstruction Lay the infant face down along you forearm, with head low, support the back and head If the obstruction is still present, turn the infant onto their back and give up to five chest thrusts. (Using two fingers push inwards and upwards towards the head against the infant’s breastbone, one finger’s breadth below the nipple line). If the obstruction odes not clear after three cycles, dial 999 for an ambulance.Continue until help arrives. CHILD Mild obstruction Encourage them to continue coughing Remove any obvious obstruction from the mouth. Severe obstruction Give up to five back blows with the heel of your hand. Check the mouth and remove any obvious obstruction. If the obstruction is still present, give up to five abdominal thrusts. Continue as for an infant. If I can not remove the obstruction dial 999 5. 2 Demonstrate how to treat an infant and a child who is choking. See answer 5. 1 5. 3 Describe the procedure to be followed after administering the treatment for choking.See answer 5. 1 6. 1 Describe the common types of wounds. These are several types of wounds that can result in bleeding: * Incised: a clean cut, for example from a knife * Lacerated: a jagged cut, for example from barbed wire * Puncture: a penetrating wound, for example from a nail * Graze: a surface wound, for example from a sliding fall * Contused: a bruise, with bleeding under the skin. 6. 2 Describe the types and severity of bleeding and the affect that it has on an infant and a child Please see attached chart. 6. Demonstrate the safe and effective management for the control of minor and major external bleeding. Any open wound is a risk of becoming infected. It is very important to maintain good hygiene procedures to prevent infection between yourself and the injured infant or child. I should always wear disposable gloves and make sure that any cuts on your own hands are covered The most effective way of minimising blood loss from major bleeding is to apply direct pressure over the wound. If the injury is on an arm or a leg, raising the limb will slow down the blood flow and help to stop the bleeding.Minor bleedingFirst aid treatment * Wash and dry your own hands an put on disposable gloves * Clean the cut, if dirty, under running w ater, and pat dry. * Cover the cut temporarily while you clean the surrounding skin with soap and water, and pat the skin dry * Cover the cut completely with sterile dressing or non-allergenic plaster Major bleedingFirst aid treatment * Wash and dry your own hands and put on disposable gloves * Apply direct pressure to the wound with a pad or sterile dressing. * Raise and support (if the injury is on a limb) * Lay the casualty down to treat for shock Bandage the pad or dressing firmly to control bleeding * If bleeding seeps through the first bandage, cover with a second bandage. 6. 4 Describe how to administer first aid for minor injuries. In most first aid situations with children, injuries are likely to be relatively minor, usually with very little blood loos. A common minor injury involving bleeding with children is nosebleed. This usually occurs when tiny blood vessels inside the nostrils burst, either as result of an injury to the nose, or from sneezing, picking or blowing the nose. The first aid treatment for a nose bleed is a follows: Reassure the child and ask them to sit down. * Advise them to tilt their head forwards * Tell the child to breathe through their mouth and to pinch the soft part of the nose (they may need help to do this). * After 10 minutes, release the pressure from the nose. If the bleeding has not stopped, pinch the nose again for two further periods of 10 minutes. * Once the bleeding has stopped, clean around the nose with lukewarm water. * Tell the child not to blow or pick their nose for a few hours (because this may disturb blood clots that may have formed in the nose).Do not let the child’s head top back as blood may run down the throat and cause choking. If the nosebleed is severe, or if it lasts longer than 30 minutes, the child should be taken to hospital. 7. 1 Describe how to recognise and manage an infant and a child who is suffering from shock. The main signs of shock are: * Pale, cold, clammy skin (lips could become blue in severe shock) * Sweating * Weakness and dizziness * Feeling sick and possibly vomiting * Feeling sick and possibly vomiting * Feeling thirsty * Rapid, shallow breathingThe main first aid treatment for shock is: – Give lots of comfort and reassurance. – Lay the casualty down, raise and support their legs. – Use a coat or blanket to keep them comfortably warm – Do not give them anything to eat or drink – Check breathing and pulse frequently. – If the child becomes unconscious, put them in the recovery position – If breathing stops, follow the DRABC resuscitation sequence. 7. 2 Describe how to recognise and manage an infant and a child who is suffering from anaphylactic shock.Anaphylactic shock is a severe allergic reaction which can be life-threatening. It is usually triggered by a substance, to which the casualty is highly sensitive, for example, drugs such as penicillin, insect stings or food such as peanuts. The main signs o f anaphylactic shock are: * Difficulty in breathing, wheezing or gasping for air * General signs of shock * Swelling of the tongue and throat * Puffiness around the eyes * Extreme anxiety The main first aid treatment for anaphylactic shock is: * Send for an ambulance Check whether the child has their own medication and help them to use it if trained to do so * Reassure and comfort the child * Treat for shock * If the child becomes unconscious, put them in the recovery position * If breathing stops, follow DRABC resuscitation sequence Children who are known to suffer from anaphylaxis will usually carry their own medication with them at all times. This is usually in the form of an EpiPen or similar device. An EpiPen is easy to use, although special training should be undertaken and you should always check the policies and procedures in my setting.

Development Of Mathematical Understanding Education Essay

1.0 Introduction1.1 What is seminal fluid ; how it is made and what is it composed ofSeminal fluid is a substance found in many male species sexual generative secretory organs. Semen is the nebulose white organic structure fluid that is emitted from the urethra of the phallus during interjection. It is made up of a assortment of molecules and cells such as leukocytes, proteolytic and other enzymes every bit good as fruit sugar and is a medium for elimination and transit of sperm cell. In the human male species, production occurs in the prostate secretory organs and gonadal which are slightly thankless sex accoutrement secretory organs until they malfunction or cease to work at all with the prevailing effects being drastically lower the rates of birthrate. Semen is composed largely of H2O, likely about 90 % by weight. After that, it ‘s a mixture of amino acids ( proteins ) , minerals, saccharides ( sugars ) , and a little figure of other things. Semen has a basic pH degree intending it is the antonym of acidic by nature – this is to antagonize and neutralize the vagina ‘s acidic pH and increase the sperm cell ‘s opportunities of endurance. Beginning: ( hypertext transfer protocol: //www.orgasmpower.net/semen-production.html ) Besides sperm, seeds is made of secernments from the seven lower urinary piece of land constructions. These constructions include: seminal cysts ( which account for 60-70 % of the fluid ) , prostatic secretory organ ( which accounts for 20-30 % ) and the staying per centum is shared by the epididymis, vessel deferens, ampullae of the vessel, Cowper ‘s secretory organs and secretory organs of Littre. Semen itself has high concentrations of K, Zn, citric acid, fructose, phosphorylcholine, spermine, free amino acids, prostaglandins and enzymes, which nourish and protect the sperm. Beginning: ( hypertext transfer protocol: //www.menstuff.org/issues/byissue/semen.html # funfacts )SourceA : hypertext transfer protocol: //www.proceptin.com/phc/sperm-cell.phpMain Production sitesASeminal fluid is largely produced in four topographic points ; in the seminal cysts, the male testicles, the prostate secretory organ and in the Cowper ‘s secretory organs. The Seminal Vesicles: This is where the milklike white protein based substance ( semenogelin I and II ) that seeds largely consists of is chiefly produced ( Ulvsback et al. 1992 ) .A These semenogelins interact with each other and coagulumate after interjection ( Aumuller and Riva 1992 ) . ( Spermatozoa wellness depends on this substance for foods which they will utilize to prolong them on their manner to fertilise the female ova.A This fluid is besides alkalic in nature and helps to neutralize the acidic conditions within the female generative system. The Male Testes: This is the organ where the production of sperm cells occurs. Spermatozoa cells are cultivated here until they mature. After that they are so stored in the Ampulla where they wait to be ejaculated out of the organic structure. They are besides protected by glycocalyx secernments from the testicle, motorial canals, epididymis and accessary secretory organs ( Schroeter et al. 1999 ) . The Prostate Gland: The prostate secretory organ besides produces an alkalic solution that acts as a protective barrier for the sperm cells against the sourness of the female sexual generative environment. The pH of the fluid is maintained above 7 by the action of prostate prostasomes ( et Al. 1999 ) . The fluid produced, is a protastic serine peptidase and helps the liquification of the semenogelins clot ( Peter et al. 1998 ) The prostate is besides an of import beginning of superoxide anion aggregators in worlds ( Gavella et al. 1996 ) A The Cowper ‘s Glands: These secretory organs produce a clear slippery liquid besides known as pre-cum which is excreted during arousal or sexual stimulation.A It is produced by the Cowper ‘s or bulbouretheral secretory organs and creates a medium for which sperm can be transported and swim in through the male generative piece of land and acts as a lubricator to cut down clash during sexual activity.Seminal fluid Composition and mapsSemens contains citric acid, free amino acids, fructose, enzymes, phosphorylcholine, prostaglandin, K, and Zn. The mean volume of seeds produced in a individual interjection varies from 2 to 5 milliliter. The seeds from a individual interjection may incorporate between 40 million and 600 million sperm, depending on the volume of the semen and the length of clip since the last interjection. Samples used for medical intents are obtained by holding the giver masturbate. If a sample can non be produced without sexual intercourse, non-reactive rub bers can be used to roll up the seeds. The procedure of secernment of seminal fluid in male mammals is finally under androgenic and estrogenic control, with a intensifying consequence happening between these two types of gonadal steroids ( Reaside et al. 1999 ) . Oxytocin secreted by the posterior hypophysis, lactogenic hormone secreted by the front tooth can besides command activity of sexual accoutrement secretory organs in mammals ( Gemmell and Sernia 1989 ; Kumar and Farooq 1994 ; Gonzalez et Al. 1994 ; Watson et Al. 1999 ) . There is a general consensus that the three major functional facets of seminal fluid are, its function in sperm competition, its map to help birthrate and in conclusion its function in the transmittal of venereal diseases. This is due to the composing of the seminal fluid being attributed to the secernment of many different tissues and that are under the control of a assortment of different constituents of the neuroendocrine system. The functionality of the seminal fluid constituents may be duplicated but in the procedure they will synergize and complement each other. As an illustration, increased immunosuppressive action of the seminal fluid on the female generative piece of land aimed at increasing sperm viability may besides ease the transmittal of sexually catching pathogens, therefore increasing the choice force per unit area on females to get the better of immunosuppression. ( Birkhead et al. 1993 ) . Seminal fluid is responsible for sperm capacitation for the ability to fertilise female ‘s egg cell. Besides some proteins secreted by male accessary secretory organs have been implicated in the procedure of sperm capacitation. ( Gillott 1996 ) . Structural proteins of the spermatophre that are secreted by sex accoutrement secretory organs, such as trehalase and sugars such as trehalose, may play a function in the activation of sperm within the female ‘s Bursa copulatrix ( Yaginuma et al. 1996 ) . The procedure of capacitation of sperm involves the acquisition of a coat of saccharides that from the glycocalyx ( Schroeter et al. 1999 ) . Most of those saccharides are attached to proteins organizing glycoprotein composites that are produced by accessary secretory organs and other tissues of the male generative system. Acquisition of a glycocalyx is indispensable in some taxa for the attainment of full capacitation of sperm and fertilizing ability. ( Schroeter et al.1999 ) . In work forces, accessary secretory organs secrete 5†²-necleotidase, an enzyme that hydrolyses nuleotides into phosphate and nucleosides, which may play a function in the alteration of sperm surface during capacitation ( Konrad et al. 1998 ) . Capacitation in human sperm is besides increased by tripeptide amides found in seminal plasma ( Khan et al. 1992 ) . Other endocrines and substances are besides found in seminal fluid such as, edothelin which facilitates transit of sperm and besides heighten sperm motions through the womb by myometrial contraction stimulation ( casey et Al. 1992 ) . The same is the instance with bradykinin which helps transporation by its smooth musculus loosen uping belongingss ( Charlse Worth et Al. 1999 ) .1.2 Which metals have been found in seminal fluid and why?The interaction between metals and biomeolecules are important and major in biological categorizations. The metals preponderantly determine many metabolic reactions and fewer of them cat as the aetiological agents in environmentally induced neurological upsets. Aluminum, Zinc, Mg, Ca and lead hints can be round in seminal fluid in edge ionic signifier. These metals are of course found in minor hints and have an array of effects and utilizations and are collected in different avenues. It has been suggested that heavy metals may hold inauspicious impacts on male generative wellness [ Benoff S, Jacob A, Hurley, 2000 ; Telisman.S et Al, 2000 ] even at comparatively low exposures [ ; Telisman.S et Al 2007 ] . The heavy metals may adversely impact the male generative system, either by bring oning hypothalamic-pituitary axis break or by direct seeds quality decrease during spermatogenesis [ Wyrobek AJ et Al 1997 ] . Several metals are suspected endocrinal disruptor compounds and/or generative poisons such as chiefly lead ( Pb ) and Cd ( Cd ) . Human populations could be exposed to heavy metals at hint concentrations normally through consumption of contaminated H2O and nutrient or contact with contaminated air or dirt. Blood and seminal Pb concentrations every bit good as seeds quality among both occupationally exposed and unexposed work forces has been studied and concluded to hold a important opposite association [ De Rosa M et Al 2003 ; JurasoviA†¡ J et Al 2004 ; Telisman.S et Al, 2000, Eibensteiner L et Al 2005 ] . Cadmium has been connected to impaired seeds quality and altered hormonal degrees in work forces [ Pant N et Al 2003, Telisman.S et Al, 2000, Akinloye O et Al 2006 ; Zeng X et Al 2002 ] . Although Cd has been considered as an hormone disruptor, the mechanisms involved are non yet clear [ Henson MC et Al 2004 ] . Mercury ( Hg ) has been found to bring on abnormalcies in sperm morphology and motility in animate being vito surveies [ Mohamed MK et Al, 1987 ; Rao Mv et Al, 1989 ] . Choy et Al. [ Choy CM et Al, 2002 ] described Hg concentrations in seminal fluid and sperm abnormalcies in subfertile males. But contrary to that, Meeker et Al. [ Meeker JD et Al 2008 ] discounted that cl aim after happening no relationship between seeds quality and Hg degrees in blood. hypertext transfer protocol: //www.ehjournal.net/content/10/1/6ZincThe intent of seminal plasma Zn on sperm maps has been a subject of involvement to many scientists. Zinc organs from the prostate is good established and found in seminal plasma as Zn citrate or edge to glycoprotein derived from seminal cysts ( Marmar et al. 1975, Arver 1982, Arver and Eliasson 1982 ; Kavanagh 1983 ; Lafond et Al. 1986 ) has been recognised since 1921 ( Bertrand and Vladesco, 1921 ) It has been found that Zn is indispensable to the decondensation of chromatin at the right clip every bit good as stableness. ( kvist et Al. 1987,1988 ) . Zinc is thought to play a function as a refinisher of an built-in mechanism for head-tail withdrawal of sperm cell ( Bjorndahl and Kvist, 1982 ) . The entire benefit or injury of Zn is vague because it has been reported that high degrees of Zn concentrations have been related to lowered sperm mortality, whilst others have reported that high Zn content in seminal plasma to be associated with a high grade of sperm cell motility ( Stankovic and Mikac-Devic, 1976 ; Caldamone et Al. 1979 ) . Zinc lack is associated with hypogonadism and deficient development of secondary sex features in worlds ( Prasad, 1991 ) . Besides high Zn concentrations have been reported to deject oxygen consumption in the sperm cell ( Huacuja et al. , 1973 ; Foresta et al. , 1990 ) , and albumin-induced acrosome reaction ( Foresta et al. , 1990 ) . Zinc has besides been found to be responsible for the antibacterial activity of seminal plasma ( Fair et al. 1976 ) and decreases in degrees are seen in prostate infections ( Marmar et al. 1975, Abyholm et Al. 1981 ; Papadimas et Al. 1983 ) . The entire Zn content in seeds from mammals was found to be at high degrees, and Zn has been found to be critical to spermatogenesis. But Zn can besides do wasting of the seminiferous tubules in the rat and ensuing in the failure in spermatogenesis ( Millar et al. , 1958 ; Underwood, 1977 ; Endre et al. , 1990 ) . Besides, high concentrations of Zinc have been reported to deject oxygen consumption in the sperm cell ( Huacuja et al. , 1973 ; Foresta et al. , 1990 ) , and albumin-induced acrosome reaction ( Foresta et al. , 1990 ) . Consiquently there have been conflicting studies on the consequence of seminal Zn on sperm motility ( Stankovic and Mikac-Devic, 1976 ; Danscher et al. , 1978 ; Caldamone et al. , 1979 ; Lewis-Jones et al. , 1996 ) . One such struggle arises when it is demonstrated that chelation of Zn ions affects sperm motility ( Saito et al. , 1967 ; Danscher and Rebbe, 1974 ) , and it has been suggested that bioavailable Zn edge to vesicular high molecular weight proteins instead than entire seminal Zn should be a step of the consequence of Zn on sperm map ( Bjorndahl et al. , 1991 ; Carpino et al. , 1998 ) . hypertext transfer protocol: //molehr.oxfordjournals.org/content/5/4/331.full.pdf+html Like zinc Mg besides originates chiefly from the prostate secretory organ and the degrees of this component in seminal plasma reflect prostate map ( Eliasson and Lindhomer, 1972 ) . The Mg degrees normally closely correlative with those of zinc concentrations ( Adamopoulos and Deliyiannis, 1983 ) .Lead a metal best known for being environmentally harmful doing it teratogenic and abortifacient. Lead disposal in animate beings causes sterility. Lead is non of course present in high sums in the organic structure but can be increased due to industrial exposure. The lead exposure has been observed to do teratospermia and to expose positive correlativity to blood lead degrees ( Lancranjan et al.1975 ) . Seminal fluid is rich in Ca and helps modulate sperm map as the concentration of Ca in seeds determines sperm motility, the ability of sperm to travel. However surveies show that an increased concentration of Ca ion was damaging to human sperm motility.Calcium is of import for sperm physiology including motility ( Morton et al. , 1974 ; Lindemann et al. , 1987 ) , metamorphosis ( Peterson and Freund, 1976 ) , acrosome reaction, and fertilisation ( Yanagimachi and Usui, 1974 ; Yanagimachi, 1981 ) . The function of seminal Ca in sperm motility is, nevertheless, non to the full understood. Thomas and Meizel ( 1988 ) found chelation of extracellular Ca ions with EGTA to suppress acrosome reaction, but at the same clip to hold no consequence on motility.Metals are omnipresent at low degree concentrations and are ingested by the general population either voluntarily through addendums or involuntarily through consumption of contaminated nutrient and H2O or contact with contaminated dirt, du st, or air. Some metals, such as Cd, lead, arsenic, and quicksilver, are incidental xenobiotics that can be measured in most of the general popu- lation [ Centers for Disease Control and Prevention ( CDC ) 2005 ] . Because widespread human exposure and organic structure load have been demonstrated, there is turning concern for inauspicious wellness effects associated with low-level exposures encountered in the environment. Human and carnal grounds suggests that these metals may hold inauspicious impacts on male generative wellness at comparatively low lev- ELs. For illustration, Cd has been linked to hapless human seeds quality and DNA harm ( Telisman et al. 2000 ; Xu et Al. 2003 ) ; Pb may adversely impact sperm form, motility, and DNA unity ( Eibensteiner et al. 2005 ; Hernandez-Ochoa et Al. 2005 ; Jurasovic et Al. 2004 ; Telisman et al. 2007 ) ; and methyl- quicksilver is associated with sperm abnormalcies in subfertile males ( Choy et al. 2002 ) . However, human informations on nonoccupation al Exposure to these metals has been limited ( e.g. , Hg ) , missing ( e.g. , As ) , or inconsistent across surveies ( e.g. , Cd ) . We designed the present survey to research relationships between these incidental metals and seeds quality among work forces with exposure degrees that are likely to be representative of those found among the U.S. general population. Several other metals, such as Cr, Cu, manganese, Mo, Se, and Zn, are indispensable for good wellness but may be harmful above certain degrees [ Agency for Toxic Substances and Disease Registry ( ATSDR ) 2003, 2004, 2005 ; Greger 1999 ; Institute of Medicine ( IOM ) 2001 ] . For exam- ple, Cr, Mn, and Cu, which act as cofactors for a assortment of of import enzymes, have been associated with decreased seeds quality in gnawers and in worlds ( Adejuwon et al. 1996 ; Huang et Al. 2000 ; Kumar et Al. 2005 ; Telisman et al. 2000 ; Wirth et Al. 2007 ) . Mo is besides an of import cofactor for a limited num- ber of human enzymes and has demonstrated generative toxicity in carnal surveies ( IOM 2001 ) . On the other manus, low doses of metals such as Cu, Se, and Zn may hold protective effects on male generative results ( Benofft al. 1997 ; Evenson et Al. 1993 ; Lyubimov et Al. 2004 ; Olson et Al. 2005 ) and may help in antagonizing the effects of Cd, Pb, or other metals ( Telisman et al. 2000 ; Xu et Al. 2003 ) . Because the possible exists for a figure of metals to positively or negatively affect male reproduction either separately or together, we besides included these metals in our analysis. This wk represents the most comprehensive survey to day of the month on metal exposures at environ- mental degrees and human seeds quality.hypertext transfer protocol: //www.scribd.com/doc/7905524/Cadmium-Lead-and-Other-Metals-in-Relation-to-Semen-Quality-Human-Evidence-for-Molybdenum-as-a-Male-Reproductive-ToxicantTable 1.1 demoing the effects of different metals on male generative systemThe tabular array below shows what Marthur and her co-workers found on how different metals affect the human male and male animate beings ‘ generative systems. Table taken from Journal of Biological Science by Marthur et al. , 2010 The human race is going more and more industrialised and at the same time urbanised. This is one of many factors which has induced the effects of ionic edge metals in male generative systems and caused worldwide qui vive ( Chowdhury, 2009 ; Turgut et Al. 2003 ) . Marthur et al. , 2010 were looking at one of the most toxic and inauspicious effects with in the human males generative system. An inflow in natural stuffs ingestion rates and graduated table has made the presence of metal compounds in the environment of all time more omnipresent. Anthropogenetic activities have been established as one of the prima causes for ecotoxicological effects. Metallic elements are various in composing and toxic stoping points, so they can non portion an exact chemical footing in toxicology. Metallic elements in ionic signifier have a inclination to be sensitive and extremely reactive which means that they can respond with biological elements, such as the human male generative system in a figure of different ways. This in consequence allows exogenic metals to exercise toxic effects that are straight linked to steric re-arrangement which has been found to be responsible for biomolecule mal map. ( Kasprzak, 2002 and Kasprzak et al. , 2003 ) . After consumption, metals can easy flux to the male generative system where the procedure of spermatogenesis is left vulnerable to changes. Similarly, the metals can interact and respond with familial make-up of the human male endocrines. Low sperm mortality and has been established to be a direct consequence of exposure to metals. Looking back at this reappraisal it can be easy deduced that the toxicity and sensitiveness of metals can be mostly attributed to the hormonal change and spermatogenesis break and or malfunction. ( hypertext transfer protocol: //scialert.net/fulltext/ ? doi=jbs.2010.396.404 & A ; org=11 )1.3 A brief debut to aluminiumAluminum can be found bounteously in our environment. It is the 3rd most abundant component in the Earth ‘s crust, stand foring 8 % by weight of the entire constituents ( Martin, 1997 ) . The worlds are necessarily and invariably exposed to aluminium. High contents of aluminum can be found in some stones after the lithospheric rhythm where it is introduced into the Earth ‘s crust. Weathering of these stones is what causes aluminium-rich minerals to fade out, which forms indissoluble clay-like stuffs that finally are re-introduced into the Earth ‘s crust by deposit. Aluminium returns into the magma by farther subduction, which in bend completes the rhythm ( Exley, 2003 ) The attendant clay like stuffs play a important function in the lithospheric rhythm of aluminum so efficient ( Exely, 2003 ) these along with the hydroxyaluminosilicates, startle the aluminum content so that it does non over concentrate the biotic rhythm. Normally aluminium enters the encephalon through the blood-brain barrier ( BBB ) . It is suspected that the aluminum enters the encephalon by receptor-mediated endocytosis as a compound with beta globulin ( Roskams and Connor, 1990 ) . it has been reported that aluminum can come in into the encephalon as a compound with beta globulin which is bound to citrate through a specific transporter, Xca?’ ( l-glutamate/l-cysteine ) system money changer is the most likely agent as explained by Nagaswa. ( Nagasawa et al 2005 ) . High aluminum consumption has been related to the appearence a neurodegenerative disease ( Perl & A ; Moalem, 2006 ; Kawahara, 2005 ) . Aluminium has no biological benefit ( Yokel 2002 ) . It is a poison associated with some medical conditions such dialysis brain disorder ( Alfrey etA al. , 1976 ) , osteomalacia ( Parkinson etA al. , 1979 ) , and it has been found to hold links with many other diseases including Alzheimer ‘s disease ( Exley 1999 ; Gupta etA al. , 2005 ) , Parkinson ‘s disease ( PD ; Yasui etA al. , 1992 ) , and amyotrophic sidelong induration ( Kurland, 1988 ) .1.4 How are worlds exposed to aluminium?There are several avenues which worlds can be exposed to aluminium due to its natural copiousness in the environment. Traces can be found in nutrient, H2O and air and even more sums can be intentionally introduced by worlds ( Miller et al. , 1984 ; Cech and Montera. , 2000 ; Lettermann and Driscoll. , 1988 ) . Aluminium compounds can be found in pharmaceuticals like alkalizers, anodynes and antiperspirants. They are besides used in H2O intervention processes as coagulators and can even be fou nd as metal in mundane consumer merchandises like foil paper and take away nutrient boxes. Aluminium compounds are besides found in about all workss. Edible workss that are of course high in aluminum include murphies, Spinacia oleracea and tea foliages ( WHO, 1998 ) . A recent survey at Keele University besides warned that unnecessarily high sums of aluminum are being used in the fabrication of baby powdered milk and that the aluminum content of expressions prepared from powdery milks was significantly higher than ready-made milks, ensuing in babies consuming up to 600 I?g of aluminum per twenty-four hours Exley and Burrell, 2010. Pregnant adult females may be potentially exposed to aluminium through the diet ( including imbibing H2O ) , dust and dirt consumption and some medicines ( Roig et al. , 2006 ) . Surveies have proven that aluminum is a major subscriber to pathologies such as dialysis dementedness, iron-adequate microcytic anemia, osteomalacia ( [ Suwalsky et al. , 2004 ] a nd [ Domingo, 2006 ] ) Over the past 40 old ages the controversial inquiry refering the possible function for aluminium neurotoxicity in lending to the pathogenesis of Alzheimer ‘s disease has been debated but remains unsolved.hypertext transfer protocol: //www.sciencedirect.com/science? _ob=ArticleURL & A ; _udi=B6TCN-4P6VDVC-2 & A ; _user=128592 & A ; _coverDate=10 % 2F08 % 2F2007 & A ; _rdoc=1 & A ; _fmt=high & A ; _orig=gateway & A ; _origin=gateway & A ; _sort=d & A ; _docanchor= & A ; view=c & A ; _acct=C000010620 & A ; _version=1 & A ; _urlVersion=0 & A ; _userid=128592 & A ; md5=ab46010ee2e9fa0fa7782f2dba6ebd0e & A ; searchtype=a1.5 What do we already know about aluminum and seminal fluidSo far I have found out that although aluminum is largely a harmful metal with no direct biological benefit ( Yokel, 2002 ) , it is found in copiousness in our environment. ( Martin, 1997 ) .Aluminium in high concentrations was linked to reduced sperm motility ability ( Hovatta et al. , 1998 ) . It is besides responsible for impaired sperm quality. Research was undertaken to detect the underlying disagreements between sperm quality and geographic location by Hovatta and co-workers. Due to miss of elucidation as to factors doing the diminution, surveies to analyze seeds quality and the concentrations of aluminum, Cd and lead in sperm cell and seminal plasma in a group of employees of a refinery and a polyolefin mill and the consequences were compared with informations obtained from samples from sperm bank seeds quality ( Hovatta et al.,1998 ) . The survey discovered that the average sperm concentrations were similar in the mill employees ( 96H106/ml ) . The sperm giver campaigners of the comparing group had a important difference of ( 104H106/ml ) in 352 giver campaigners at the sperm bank of the Family Federation of Finland ( 107H106/ml ) between May 1993 and May 1995 ( Hovvatta et al. , 1998 ) . Research done in Finland discovered that high and unchanged sperm counts have been found ( Suominen and Vierula, 1993 ; Vierula et al. , 1996 ) . In contrast to that, two necropsy series of middle-aged Finnish work forces showed an addition in the incidence of upsets of spermatogenesis between the old ages 1981 and 1991 was unveiled ( Pajarinen et al. , 1997 ) . Meanwhile, decreased birthrate in Britain ran parallel with that in Finland, based on differences in the clip to construct ( Joffe, 1996 ) . Regional differences were besides apparent in the USA, with the highest mean sperm concentration being found in New York ( 131.03106/ml ) and ( A © European Society for Human Reproduction and Embryology ) 115 the lowest in California ( 72.73106/ml ) ( Fisch et al. , 1996 ) . A little addition in sperm concentration between the old ages 1972 and 1993 was seen in Seattle, Washington ( Paulsen et al. , 1996 ) . It has been suggested that environmental factors played a function in the diminution observed in Europe, particularly environmental oestrogens ( Sharpe and Skakkebaek, 1993 ) . Oestrogens have besides been suggested to hold caused the addition seen in the incidence of cryptorchidy and testicular malignant neoplastic disease ( Sharpe and Skakkebaek, 1993 ; Skakkebaek and Keiding, 1994 ) . Heavy metals are potentially pollutants that may be harmful to sperm production. Exposure due to business or geographics to several metals is known to impair sperm quality ( Schrag and Dixon, 1985 ) . Substances such as lead and Cd concentrations have been measured in human seeds, seminal plasma, sperm cell, blood and piss, and high concentrations have been found to be related to impaired sperm quality ( Lancranjan et al. , 1975 ; Plechaty et al. , 1977 ; Braunstein et al. , 1978 ; Pleban and Mei, 1983 ; Stanwell-Smith et al. , 1983 ; Thomas and Borgan, 1983 ; Saaranen et al. , 1987, 1989 ; Chia et a l. , 1992 ; Hu et al. , 1992 ; Xu et al. , 1993 ) . In several experiments, many metals have besides been shown to be harmful with respect to testicular map and sperm production ( Alabi et al. , 1985 ) . Aluminum may good be one of the possible pollutants, because it reduces the weight of the testicles and was seen to do reduced epididymal sperm counts in the mouse ( Llobet et al. , 1979 ) . When aluminum is ingested in big sums, it leads to accumulation in certain mark variety meats such as the homo and animate being testicular tissues which consequences in harm occurring. The of long-run ingestion of aluminum showed suppressive effects on sexual behavior, lessening in birthrate and aggressive behavior ( Bataineh et al. , 1998 ) . There is grounds implicating androgenic endocrines involved in mechanisms of aluminum toxicity on male reproduction ( Sharpe, 1990 ) . To add to that, Guo et Al. ( 2005a ) carried out trials that proved that aluminium disposal significantly increased azotic oxide ( NO ) production and decreased both testicular adenosine 3aˆ?,5aˆ?-cyclic monophosphate ( camp ) and testosterone degrees. They demonstrated that inordinate NO activated inducible NO synthase ( NOS ) which may be involved in generative toxicity of aluminum. Information refering the generative toxicity and testicular disfunction of aluminum still needs more research. Besides, the function of propolis against aluminum induced impairments in the generative ability of rats has non yet been discovered. The survey taken on by ( Yousef and Salama,2009 ) , was aimed at finding the generative toxicity of aluminum chloride in grownup male rats. It showed that aluminum enhanced lipid peroxidation in plasma, testicles, encephalon, kidney, lung and liver of coneies, and besides in civilization of coney sperm ( [ Yousef, 2004 ] , [ Yousef et al. , 2005 ] and [ Yousef et al. , 2007 ] ) . Besides, to measure the protective consequence of propolis against the possible testicular disfunction caused by aluminum chloride. Table 1. Relative weights ( g/100A g organic structure weight ) of sex variety meats of male rats treated with AlCl3, propolis and AlCl3 + propolis.ParameterExperimental groupsControlAlCl3PropolisAlCl3+PropolisTestiss 0.72A A ±A 0.093 0.58A A ±A 0.061** 0.78A A ±A 0.0739*** 0.66A A ±A 0.091* Seminal cyst 0.35A A ±A 0.061 0.20A A ±A 0.081** 0.39A A ±A 0.105*** 0.31A A ±A 0.119* Epididymis 0.27A A ±A 0.036 0.19A A ±A 0.037** 0.30A A ±A 0.036*** 0.24A A ±A 0.041* Prostate gland 0.16A A ±A 0.023 0.14A A ±A 0.021 0.16A A ±A 0.017 0.15A A ±A 0.02 Full-size tabular array Valuess are expressed as meansA A ±A SD ; nA =A 10 for each intervention group. Significant difference from the control group at **PA & lt ; A 0.01. Treatment of male rats with AlCl3 significantly ( PA & lt ; A 0.01 ) decreased sperm concentration and motility rate. Meanwhile increased dead and unnatural sperm, as compared to command and propolis groups were seen in Table 2. Treatment with propolis entirely showed no important effects on sperm concentration and motility. while caused important ( PA & lt ; A 0.05 ) lessening in dead and unnatural sperm compared to command group. On the other manus, intervention with propolis in combination with AlCl3 caused significantly alleviated the diminution in sperm concentration and motility, and significantly decreased the per centum of dead and unnatural sperm compared to AlCl3 group. This means that propolis minimized the toxicity of AlCl3.ignificant difference from the AlCl3-intoxicated group at # PA & lt ; A 0.05 and # # PA & lt ; A 0.01. Table 2. Changes in sperm concentration ( Sp. Conc. , A-106/ml ) , motility ( % ) , and dead ( % ) and unnatural ( % ) sperm of male rats treated with AlCl3, propolis and AlCl3A +A propolis.ParameterExperimental groupsControlAlCl3PropolisAlCl3 + PropolisSp. Conc. 212A A ±A 15.5 148A A ±A 8.1** 233A A ±A 12.1 # # 199A A ±A 7.5 # # Motility 72.4A A ±A 1.89 50.9A A ±A 2.64** 79.7A A ±A 1.64 # # 70.5A A ±A 1.43 # # Dead 25.2A A ±A 1.95 45.1A A ±A 2.21** 20.2A A ±A 1.78* # # 28.8A A ±A 3.01 # # Abnormal 14.6A A ±A 1.96 21.3A A ±A 2.312** 11.6A A ±A 1.27* # # 16.7A A ±A 1.337 # # Full-size tabular array Valuess are expressed as meansA A ±A SD ; nA =A 10 for each intervention group.Significant difference from the control group at *PA & lt ; A 0.05 and **PA & lt ; A 0.01.Significant difference from the AlCl3-intoxicated group at # PA & lt ; A 0.05 and # # PA & lt ; A 0.01. This survey observed the consequence of aluminum chloride on sperm motility. ( Table 2 ) . Additionally, Dawson et al. , 1998 E.B. Dawson, S. Ritter, W.A. Harris, D.R. Evans and L.C. Powell, Comparison of sperm viability with seminal plasma metal degrees, Biol. Trace Elem. Res. 64 ( 1998 ) , pp. 215-223.Dawson et Al. ( 1998 ) found that high concentrations of aluminum in human sperm cell and seminal plasma are correlated with reduced sperm motility and viability. Motility is important in enabling the sperm to swim through the female generative piece of land and make the egg cell to accomplish fertilisation ( Aitken, 1995 ) . The observation can be concluded by stating that the lessening in sperm motility was caused in portion to the attendant decrease in testosterone production ( [ Guo et al. , 2005a ] and [ Yousef et al. , 2005 ] ) following aluminum intervention. Table 3. Plasma testosterone concentration ( ng/ml ) and activity of testicular 17- ketosteroid reductase enzyme ( U/min/mg protein ) , and testes protein content ( mg/g tissue ) of male rats treated with AlCl3, propolis and AlCl3 + propolis.ParametersExperimental groupsControlAlCl3PropolisAlCl3 + PropolisTestosterone 1.31A A ±A 0.244 1.00A A ±A 0.115* 1.51A A ±A 0.113* # 1.15A A ±A 0.064 # 17-Ketosteroid Reductase enzyme 14.6A A ±A 2.02 10.2A A ±A 1.13** 19.1A A ±A 1.49** # # 12.8A A ±A 2.03* # Protein content 76A A ±A 4.4 60A A ±A 4.7** 105A A ±A 5.3** # # 75A A ±A 5.2 # # Full-size tabular array Valuess are expressed as meansA A ±A SD ; nA =A 10 for each intervention group.Significant difference from the control group at *PA & lt ; A 0.05 and **PA & lt ; A 0.01.Significant difference from the AlCl3-intoxicated group at # PA & lt ; A 0.05 and # # PA & lt ; A 0.01. Datas in Table 3 showed important lessening in plasma testosterone concentration ( PA A 0.05 ) and testicular protein ( PA A 0.01 ) in rats treated with AlCl3 compared to command. While, propolis significantly increased testosterone and protein content and alleviated the negative effects for AlCl3 in group 4 on these parametric quantities. Aluminium chloride exposure displayed gonadotoxic effects in male rats and maternal decease was associated with foetal decease in pregnant rats. The exposure to aluminum increases the incidence of fetal abnormalcies in rats and mice ( Belles et al. , 1999 ) . The survey of Guo et Al. ( 2005a ) demonstrated that exposure to aluminium lowered plasma and testicular testosterone degrees in mice. It was suggested that the terrible decrease in male libido and birthrate following the aluminium disposal might be a consequence from inordinate aluminum accretion in the testicles and low testosterone concentrations. High degrees of aluminum in aluminium-treated mice were evident at hebdomad 3 before the effects on male libido and birthrate manifested. The disagreement was reasoned such that aluminium accretion failed to instantly impact the enzymes for androgen biogenesis or bring forth a possible perturbation in hypothalamic-pituitary-gonadal axis. However, the present survey showed that AlCl3 caused important diminution in the activity of 17-ketosteroid reductase after 70A yearss intervention ( Table 3 ) . Table 4. Changes in the activities of catalase ( CAT ; mol/h/g tissue ) and glutathione S-transferase ( GST ; I?mol/min/g tissue ) , and the degrees of thiobarbituric acid-reactive substances ( TBARS ; nmol/g tissue ) and reduced glutathione ( GSH ; mM/g tissue ) in testicles of rats treated with AlCl3, propolis and AlCl3A +A propolis.ParameterExperimental groupsControlAlCl3PropolisAlCl3+PropolisCat 6.96A A ±A 1.140 3.01A A ±A 0.578 ** 9.95A A ±A 1.050 ** # # 5.89A A ±A 0.793 # # GST 1.08A A ±A 0.100 0.59A A ±A 0.154** 1.43A A ±A 0.299 ** # # 0.96A A ±A 0.125 # # TBARS 71.8A A ±A 5.58 195.9A A ±A 10.62 ** 60.4A A ±A 6.18 * # # 97.4A A ±A 9.58 * # # GSH 6.02A A ±A 0.694 4.15A A ±A 0.690 * 8.25A A ±A 0.902 * # # 5.74A A ±A 1.863 # Full-size tabular array Valuess are expressed as meansA A ±A SD ; nA =A 10 for each intervention group.Significant difference from the control group at *PA & lt ; A 0.05 and **PA & lt ; A 0.01.Significant difference from the AlCl3-intoxicated group at # PA & lt ; A 0.05 and # # PA & lt ; A 0.01. The control testicles are surrounded by a dense hempen tissue capsule known as the adventitia albuginea The histological survey showed that.The testies are divided into lobules by thin hempen septa ; the interstitial tissue surrounds the lobules which contain several seminiferous tubules within them. The tubules are lined with germ cells in assorted phases of spermatogonia, some primary and secondary spermatocytes, spermatids and mature sperm cell that occupy the Centre of the tubule. Between the spermatogonia and the balance of the basal lamina are the sertoli cells. The interstitial tissue is supported by Leydig cells in chief. They occur singly or in bunchs and are embedded in the rich rete of blood and lymph capillaries. Observations of testicles treated with AlCl3 revealed several changes. The accretion of exfoliated source cells within some seminiferous tubules affected their architecture and left them disorganized. Some tubules exhibited ripening apprehension. And moreover, so me source cells had little and darkly stained nuclei. Marked dilation and congestion of blood vass were noticed in the interstitial infinites. Hyperplasia of Leydig was detected in the interstitial tissue. The Leydig cells became crowded and formed dense bunchs that surrounded most of the seminiferous tubules ( Fig. 2 ) . Some subdivisions of testicles of the rats treated with propolis entirely showed that they were less or more similar to the control subdivisions ( Fig. 3 ) . Testis of rats treated with aluminium plus propolis revealed that it regained about all of its original construction and singular Restoration of the normal image of seminiferous tubules was attained. The germ cells appeared regular in form with disappearing of most cytoplasmatic vacuolization. Most of the karyon became vesicular ( Fig. 4 ) . Testes accumulate high aluminium over age in rats ( Gomez et al. , 1997 ) . Light microscopy of silver-stained paraffin subdivisions of the testicles demonstrated legion i ntracytoplasmic black-stained all right farinaceous inclusions in Leydig cells ( Reusche et al. , 1994 ) . The histological alterations in testicles of rats treated with AlCl3 ( Fig. 2 ) is coincident with the obtained informations by Khattab ( 2007 ) who studied the consequence of AlCl3 on the testicles of rats after an intraperitoneal injection was administered. The testicles showed histological disturbance including terrible harm within the seminiferous tubules and vascular devolution on the spermatogenic and sertoli cells cytol. The originative epithelial tissue of the seminiferous tubules was thinner in topographic points and spermatids became really scarce in presence. Sperm Numberss was low and there were no sperm in the lms. Besides, up on negatron microscopic surveies, in the aluminium-treated group, there were some anomalousnesss in the atomic membrane, amendss to some chondriosomes, ribosomes population lessening, and an addition in the figure of lysosomes in the sertoli cell cytol. In the primary spermatocyte cytol, there was an addition in the unsmooth endoplasmic Reticulum. Guo et Al. ( 2005b ) found that after 2 hebdomads of aluminum intervention, hurtful effects and histopathological alterations of testicular tissues were observed. However, noticeable spermatogenetic loss was viewed as necroses in the spermatids and sperm cell in aluminium-treated group at hebdomad 5. The damage caused by aluminum was accompanied chiefly by the drawn-out accretion of aluminum in the mice testest. Fig. 1.A Photomicrograph of control testicle subdivision demoing interstitial cells ( I ) and germ cells ( G ) . H & A ; E discoloration ( 400A- ) . Fig. 2.A Photomicrograph of testicle subdivision that treated with aluminum demoing germ cells ( G ) , exfoliated source cells ( E ) , hyperplasia of Leydig cells ( I ) and vacuolization ( V ) . H & A ; E discoloration ( 400A- ) . Fig. 3.A Photomicrograph of testicle that treated with propolis demoing germ cells ( G ) . H & A ; E discoloration ( 400A- ) . Fig. 4.A Photomicrograph of testicle subdivision that treated with Aluminium and propolis demoing germ cells ( G ) . H & A ; E discoloration ( 400A- ) .1.6 Purposes and aims of my undertakingIn this undertaking my chief purpose was to find the presence of aluminum in seminal fluid and sperm cell. I had to found out if aluminum was present in the seminal fluid or the sperm cell.DiscussionTHE EFFECT OF ORAL HIGH ALUMINIUM INTAKE ONRAT SPERMATOGENESISI.M.D. Rashidi. Head of section & A ; member of adept commission Dept of pathology Medical school Ahwaz medical university, Ahwaz Iran Aluminum is one of the most abundant elements in the Earth crust and enters to the organic structure through imbibing H2O, foods and drugs like antacids. Aluminium poising causes broad scope of upsets, including: a lessening in the release of neurotransmiters and suppression of electromotive force dependent Ca channels. The function of Ca on GnRH release and its action is detected so, in this perusal, the consequence of high aluminum consumption on rats spermatogenesis is investigated. The experiment performed in four groups, a control group and three experimental groups consumed 0.625, 1.25 and 2.5 milligram aluminum per gm diet for 60 yearss. Epididymis and vessel deferens were dissected cut and diluted with normal salin. In all groups weight of vessel deferens, epididymis, testicle and whole animate being, sperm count per gm deferens and epididymis tissues were determined so, the testicular tissues fixed in formol for survey of histopathology. The consequences have shown that in experimental groups which consumed 1.25 and 2.5 milligram aluminum per gm diet, the vessel deferens, epididymis, testicle and carnal weight were significantly decreased. In this animals the figure of sperm per gm tissues from vessel deferens, epididymis were reduced. The ripening apprehension is seen in seminoferous canal and it have n't spermatogenesis. Therefore, this analyzing indicated that high aluminum consumption in rat have an suppressing consequence on spermatogenesis and this consequence is dose dependant. hypertext transfer protocol: //www.sciencedirect.com/science? _ob=MImg & A ; _imagekey=B6TCR-4CB7K82-GF-1 & A ; _cdi=5177 & A ; _user=128592 & A ; _pii=S0378427403904048 & A ; _origin=gateway & A ; _coverDate=09 % 2F28 % 2F2003 & A ; _sk=998559999.8998 & A ; view=c & A ; wchp=dGLzVtb-zSkzV & A ; md5=1f1a3377fb5ad50ff2bd8ffd8947d810 & A ; ie=/sdarticle.pdf Read and summarize but cite hypertext transfer protocol: //humrep.oxfordjournals.org/content/13/1/115.full.pdf

Nfl Helmet-to-Helmet Hit Rule

Let Them Play the Game Every part of the game of football means very much to me, which is why I have a passion for the game and why I researched this topic. Helmets are one of the most important pieces of safety gear a football player can have. In October 2010, a new rule was signed off to be placed in the National Football League (NFL) rule book for the safety of NFL players. The helmet-to-helmet hit rule is as follow: using any part of the helmet to butt, spear, or ram any part of the opponent’s helmet (Azpiri). A helmet-to-helmet hit is illegal in the NFL now.The punishment for a helmet-to-helmet hit for a NFL player is being fine with a gradual increase the next times they do it and/or suspension depending on the player’s penalty history. I propose for there not to be a helmet-to-helmet hit rule. The NFL should not include the helmet-to-helmet rule, by doing so; the rule will begin by taking one of the most exciting and popular parts out of the game, hard hits. One of the reasons why I believe that is because they have safety gear on such as: helmets, shoulder pads, knee pads, and thigh pads.If they keep adding rules, pretty soon, we will be able to call it flag football without tackling. Football is a violent sport, when players sign contracts with millions of dollars attached to them; they know how violent the game has always been. Not to mention, no one has to play. If a player does not want to take a hard hit, they do not have to. I agree with Rick Cleveland when he says, â€Å"They are ruining the game we love. Football is by nature a violent sport. Nobody says you have to play. Let them play football† (Cleveland).During my research, I found many NFL players that would agree that the helmet-to-helmet rule should not be a rule. For instance, James Harrison, who plays for the Pittsburg Steelers, made a statement after a helmet-to-helmet hit on a Cleveland Brown player during a game, which read â€Å"†¦ I didn’t hit that hard, to be honest with you. When you get a guy on the ground, it’s a perfect tackle† (Harrison). As Harrison said, a tackle is a tackle, no matter where or how hard you hit them. It is to me understanding that each and every NFL football player is taught everyday to play hard and it hard. NFL players know that they are taking a massive risk of getting injured every time they step a foot on a football field, whether it be for a game or just practice. If you have the football in your possession, you should be able to take a hit anywhere on your body, even if it is on your helmet. There is no point in time where a line should be drawn. If a player makes helmet-to-helmet contact unintentionally, he should not be fined as much as if it were intentional. Helmets keep a players head safe during a game.Most NFL players still wear helmets that were made in the nineteen-nineties (Halstead). DeSean Jackson now has an anti-concussion football helmet (Chase). If helmet companies ma nufactured more anti-concussion helmets, players would be better off and the rule would definitely not need to be in play. Also, according to Halstead, in two thousand-thirteen, players will finally have price breaks from helmet companies to be able to buy newer safe helmets (Halstead). If players buy more anti-concussion helmets, they would not get injured as easy nor would the helmet-to-helmet hit rule need to take place.

Social Performance Essay Example | Topics and Well Written Essays - 1000 words - 4

Social Performance - Essay Example People in the same set of business ventures rarely come together not for merriment and diversion but for scheme against the public (Paul and Elder, 2006). Briefly describe your company and then benchmark the codes of conduct used by similar companies in the industry. Critique the codes of conduct of at least three (3) similar companies in order to write codes for your company. Bp is a company that specializes in the installation of solar powered streetlights contracted in the lighting of streets due to the increased insecurity resulting from poor lighting in most areas. Valmont industries specializes in producing lighting materials and according to Mogens Bay, ethics is the driver of an organization. The company tries to embrace a family mode of operation in the industry where each one in the organization treats as an equal. Ethics is how you treat your fellow employees and not only making decisions ethically (Bay). Employees need to be treated with compassion but the compassion has to be limited to achieve the set goals, as some duties need an override of ethics for them to be achieved. Advanced lighting technologies observe the importance and significance of ethics within its corporate governance program. Rules regarding persons and peer responsibility embody the ethics code as well as their responsibilities to the company, stakeholders, and public. The company requires individuals to demonstrate honest at all times by avoiding personal or professional conflicts. Provision of accurate, complete, relevant, and timely information to the constituents (public, stakeholders) is a requirement. A company should preserve some information from the eyes of the public and competitors, as an insight to every happening in the company is critical to the growth and achievement of its set goals. The company requires all its employees to comply with rules and regulations of the land (federal, state, provincial, and local government). General Electronics embraces ethics

The causes of the Korean War Essay Example | Topics and Well Written Essays - 3750 words

The causes of the Korean War - Essay Example On the other hand, South Korea was being led by Syngman Rhee, a nationalist and was receiving by members of the United Nations and the United States of America. Since the Korean War ended in a truce, there is a presence of the US soldiers in South Korea. This is because, officially, officially, North and South Korea are still at war and thus, there is need to ensure that the US soldiers can make timely military intervention, in the event that North Korea makes an invasion on South Korea. The same truce ensures that South and North Korea remain divided by the 38h parallel. In light of the gravity of the Korean War, the causes of the Korean War must have also been not only serious, but also cutting across socio-economic and political issues, as shall be seen in the discussion which ensues forthwith. There are scholars such as Brune1 who point out that the historical relationship of the two states also served as a strong run-up to the Korean War. As provisional governments, the North an d South divisions competed vigorously over the control of the Korean Peninsula. This always made the major surrounding players in international politics [Russia, China and Japan] to yield to the temptation of interfering with the political situation in the Korean Peninsula. ... Specifically, Kim II-Sung had made efforts to create a Stalinist empire which was built on communist ideals. This regime came complete, having a well established army known as the North Korean People’s Army (NKPA). NKPA was more than adequately stocked with Russian guns, tanks and artillery. On the other hand, South Korea had an unstable political situation. However, the political and economic situation in the United States began to change when the United States began to support Syngman Rhee as the head of the South Korean state. In the mind of the Soviet Republic, if America was going to continuously fund Rhee and South Korea, then it (Russia) was going to lose its grip on the North. This is because, with the large amount of money that the US had and was ready to spend on its allies, pressure would mount in the north to develop a friendlier outlook towards the United States. Thus, the Soviet Union sought to strengthen its hold on North Korea as hard as possible. This state of affairs continued to worsen the state of antagonism between the US and the Soviet Union over the affairs of the Korean peninsula. Later, tension and the competitive spirit between the Soviet Union and the US continued to mount when the political leaders who were being backed by the two political rivals ascended the seat of the head of the executive. On 10 May, 1948, the south held its general elections which saw Syngman Rhee become president. In response, the Soviet Union supported Kim II-Sung politically so that he was declared Prime Minister of the Democratic People’s Republic of Korea on 19 September, 1948. These events made it clear for the two political rivals that

Information essay ---education related( preferred differences between

Information ---education related( preferred differences between chinese and western education - Essay Example In the modern times when a nation needs to concentrate on the Knowledge economy’, the role of education becomes more important to be addressed in the development of human capital. This is on the grounds that when a nation has a general public of educated citizens, it increases its chances of development at all the social and economic levels. Besides, the every capital pay of a nation altogether relies on the condition of economy which is straightforwardly relative to the education rate in a nation (Leung 42). Educated individuals have different chances and have the capacity to propel in different fields for openings for work, they are versatile and can work in anyplace inside the nation to earn a living and thus enhance their expectations for everyday comforts. Educated individuals have the capacity to enhance openings for work and adequately use the rare assets henceforth lessen neediness levels. For the vast benefits of education across the world, many nations have adopted different kinds of education systems. That is why there is a big difference between Chinese and Western systems of education; many scholars have been quoted to say that â€Å"Westerners are more assertive and creative, while Easterners are more conservative and reserved.† The underlying question is†¦what makes the difference? The difference comes as a result of dissimilar education systems; their approaches to teaching and learning are quite different .In China education is seen as the best approach to land the best position that has the most impact. Therefore, from the time kids can be placed in school, they are overwhelmed with homework, retention and the steady pressure to exceed expectations. Regarding education, conservative Chinese society weights students to study mindfully for required tests expected to move onto the following level of

Employee Retention in the fast Food Industry Assignment

Employee Retention in the fast Food Industry - Assignment Example According to the paper, presently, variations in trade agreements, technology, global economics and any other such factors are directly affecting employer/employee relationships. For quite some time loyalty has been the basis for that relationship. Losing very talented employees may be very disadvantageous to the future success of the company. Outstanding employees of a company may leave because they are underpaid, dissatisfied or unmotivated, therefore, trying to retain them is likely to present many challenges to the organization. Such employees may demand higher wages; they may fail to comply with the directions of managers, fail to comply with practices of the organization, or not interact well with their colleagues. The organization’s desire to retain such employees may be further complicated by information asymmetry because lack of enough information may not help the organization to differentiate productive employees from unproductive ones. Workers frequently take credit for other employees’ success and deflect failures to others. Thus, employees may be punished or awarded for outcomes that they are not part of. Inadequate information regarding performance of employees may result in adverse selection, outstanding ones may leave, and abysmal ones may stay. The situation is likely to occur when exceptional workers are not rewarded and both productive and nonproductive ending up with the same or almost the same compensation package. The problem of keeping outstanding workers in the company is further complicated due to bounded rationality. This results due to information asymmetry because workers do not know the information to provide and the managers do not know what information to ask from their employees.

Strolling along the Narrow Paths into the Deep Forest Essay

Strolling along the Narrow Paths into the Deep Forest - Essay Example A soft waft of air tickles the leaves above creating a flip-flopping light underground – something romantically perfect for couples. Going to the forest is one of the best voyages in life to take. God indeed loves humanity as it manifests through the perfect beauty of the nature surrounding us. I can remember one sunny and blissful morning when I decided to take a trip to an outskirt nearby. Half a kilometer away, I could tell that one blissful reunion would take place later that day. Because I am a forest addict, I had the cheek to go there all by myself. Just like what most forest goers encounter, I had my share of stern tests. Before getting to the heart of the timberland, I knew that I had to go through tough challenges. Nevertheless, these challenges would not tarnish attitude towards this place since the way I feel while am at this place outweighs the few challenges I have to encounter. Therefore, no matter how many challenges I would encounter, it enhances my confidence and attitude towards the place; thus, giving me a good reason why I will always consider it the best place I can be in the world. Finally, I arrived at the doorstep of the jungle, and the first thing I saw was a cohort of vibrant buds bowing their heads down to welcome me, and although quite silly, I felt, as I was treated royally. As I hovered above my head, I could see the wild vines meshing up with each other to form a lovely wild curtain; I could also hear the birds chirping tones in mirth. It gave the impression as if they were chanting out in harmony to serenade me. I stared down and saw my leather booths muddled up with some thick mud clinging around them, but I knew the sludge was not going to stay there for long as the spiky fingers of the rye were ready to wipe them out. When I finally took several steps inward, it seemed as time has traveled so fast that day. In fact, the surroundings turned rather gloomy, although everything  was still in sight. This reminded me that and that I would finally leave and get back to the normal life.  

Individual Exercise Essay Example | Topics and Well Written Essays - 500 words

Individual Exercise - Essay Example On the other hand, not all investors are able to enter in this market because of the huge amounts of capital that is required in order to start up a company. It is for this reason that the threat of new entrants in this market is moderate. The bargaining power of customers also affects the nature of competition in this market. Customers in this case are airlines who purchase the commercial jets. These companies have no substitute product and therefore have to buy aircraft. This makes the bargaining power of customers to be low. The level of competition is high in this market is because of new entries in the market who have decreased their prices significantly. This has in turn increases the pricing pressure on a company like Boeing. For instant, Boeing 737MAX-7 with a capacity of 130 passengers is listed at $85 million, while Bombardier’s largest C series model with the same capacity goes for $71 (Forbes, 2014). Suppliers in this industry are seen to be having a low bargaining power because their customers only include aircraft manufacturers. These manufacturers are few as compared to the number of suppliers in the market. Fly Dubai is in its development phase. Flydubai is committed to making air travel affordable for its customers (Flydubai, 2014). This gives them the opportunity of attracting many customers and retaining them. The threat that this airline faces is high competition in this market from more established airlines that operate worldwide. The fact that it is low cost brings out the threat of not being able to cater for the operating costs incurred by the company. The competitive structure of DRAM market is characterized by many competitors who have expanded their capacity into the production of semiconductor chips. For this reason, companies need to be innovative in order to succeed in this market. There is also no barrier to enter into this market which encourages many companies to enter this market.

The World is becoming flatter Assignment Example | Topics and Well Written Essays - 250 words

The World is becoming flatter - Assignment Example I believe that we are better informed in today’s information society because we have a lot of communication and learning tools that have been introduced to us through the use of information technology. Schools and colleges are implementing the use of ICT tools so that students can get equipped with the most modern technological tools which help them enhance their learning process. Matthews and Schrum (2003, p.125) have found that children, who incorporate the use of IT in their education or those who take help from the internet for research purposes, get higher GPAs than those who are not familiar with IT or who get distracted when they are online. Internet is being widely used in research and development purposes and the new softwares and applications that are coming in the market with each passing day tend to make us better informed about the world and ourselves. One example is that people can learn about diseases through the internet and ways to cope with them too. This hel ps them make decisions about their health. All of these facts prove that the world is becoming flatter, because every opportunity and facility is being offered to us right at our

Term “integrity” Essay Example for Free

Term â€Å"integrity† Essay Integrity It is necessary to outline that the term â€Å"integrity† is considered polysemantic meaning it is provided with lots of meanings. Integrity is the most important terms used in virtue ethics, for example. Integrity is used in the scientific and technological fields. Therefore, this term is often puzzling and perplexing. Sometimes people use integrity as a synonym to â€Å"moral† trying to distinguish that person is acting with integrity. However, researchers noted that people of integrity may act immorally, even if they are unaware of their immoral actions. Thus it is necessary to say that a person may be of integrity even if he holds importantly mistaken perspectives on ethics and morality. Firstly, integrity is defined a quality of a person’s character. Then people thinking of integrity of wilderness region or ecosystem, art forms, computerized database, etc. Integrity is applied mostly to the objects and it suggests purity, intactness and wholeness of an object. These meanings are often applied to people. Speaking about regions, integrity means that a region isn’t corrupted by side-effects of development and its advance. Region of integrity suggests wilderness and uncorrupted or virgin. In computer science, integrity means that computer database is able to maintain power and resist to errors, integrity of defense systems suggests that system isn’t breached. In music, for example, musical work has integrity if its musical structure is provided with completeness which is coordinated and has related music ideas. Simply saying integrity in music means that music piece is whole, intact and pure. Integrity is found in many aspects of human’s life. For example, there are ideas of intellectual, professional and artistic integrity. Nevertheless, integrity has found its application mostly in philosophy meaning human’s general character. As it is noted â€Å"philosophers have been particularly concerned to understand what it is for a person to exhibit integrity throughout life†. In philosophy, when a person acts with integrity on a particular occasion it means that integrity is explained as broader feature of person’ character. There is a claim that person should possess integrity. Ordinary discourse about integrity involves two fundamental intuitions: first, that integrity is primarily a formal relation one has to oneself, or between parts or aspects of ones self; and second, that integrity is connected in an important way to acting morally, in other words, there are some substantive or normative constraints on what it is to act with integrity. How these two intuitions can be incorporated into a consistent theory of integrity is not obvious, and most accounts of integrity tend to focus on one of these intuitions to the detriment of the other. Integrity is a matter of persons integrating various parts of their personality into a harmonious, intact whole. Understood in this way, the integrity of persons is analogous to the integrity of things: integrity is primarily a matter of keeping the self intact and uncorrupted. A related approach to integrity is to think of it primarily in terms of a persons holding steadfastly true to their commitments, rather than ordering and endorsing desires. â€Å"Commitment† is used as a broad umbrella term covering many different kinds of intentions, promises, convictions and relationships of trust and expectation. One may be, and usually is, committed in many different ways to many different kinds of thing: people, institutions, traditions, causes, ideals, principles, projects, and so on. The self-integration and identity views of integrity see it as primarily a personal virtue: a quality defined by a persons care of the self. Persons of integrity treat their own endorsements as ones that matter, or ought to matter, to fellow deliberators. Calhouns account of integrity promises to explain why it is that the fanatic lacks integrity. It seems intuitively very plausible to distinguish between fanatical zeal and integrity, but the self-integration and identity views of integrity threaten to make the fanatic a paradigm case of a person of integrity. References Graham, Jody L. (2001). Does Integrity Require Moral Goodness? Ratio 14, 2, 234-251. Harcourt, Edward (1998). Integrity, Practical Deliberation and Utilitarianism. Philosophical Quarterly, 48, 189-198. Herbert, Mark R. (2002). Integrity, Identity and Fanaticism. Contemporary Philosophy 24, 25-29.

Skills practice Essay Example for Free

Skills practice Essay There are many safety aspects that need to be considered when designing a training programme. A warm up is very important as it increases the blood flow, stimulates the level of activity and decreases the risk of injury and also may well help one concentrate better on the activity being performed. It also helps to prepare the body for the physical exercise that should follow it. It gently raises the pulse rate, which in turn prepares the heart for more strenuous activity. More oxygen and other fuels are transported to the muscles by the body. In a warm up there should be three phases; a pulse raiser, stretching and a skills practice. A cool down must also be preformed at the end of the session as this allows the body to recover by starting to remove the build up of lactate, and by stretching it allows the muscle fibres return to their initial condition. This helps return the body to its normal state in the quickest time possible. The blood flow will be kept high, waste products are washed out and the temperature slowly returns to normal. The equipment should always be checked before a match as if anything is not working properly or broken it could result in serious injury. This could be done by checking the bats for splits in them, using the correct rounders ball and making sure the posts are securely in position and that they cannot fall or cause an injury to a player.  The clothing should not be baggy or get in the way while playing, and if playing in warm weather light, airy clothes should be worn so as to prevent the player getting too hot and feeling faint. Jewellery should not be worn at all as this can get caught and cause damage or injury. Trainers must be worn as there will be running involved and so flat shoes will be needed. The playing surface should be on grass and should be firm. The pitch should be marked out with the course to run in a diamond shape. The posts and batting/bowling boxes should be clearly marked out.  The batting team must stand far back from the where the playing batter is standing as they could get hit either by the bat or if the ball goes behind. Also, players standing by a post must stand on the inside; otherwise it is obstruction, which could also cause injury by the batter running into the fielder. Throughout my training programme I managed to keep a high level of interest through each session, as each was very different, allowing me to try knew skills out each time. However, as I found chin-ups so hard, it made me dread doing that particular station, but at the same time more determined to do better. For each station and session I wanted to try and beat my own personal best, which made it a task and goal for me to reach, thus making it more interesting for me to complete. Planning of Monitoring  The exercises were in the correct order as no station followed another by using the same muscular groups. They were set in an order of using torso, arms, and legs and then repeated again. This made it easier to continue, and not too much strain was placed on a specific muscular group.  They were the correct choice as they tested my different abilities and helped improve my skills in diverse areas. This can help me while playing a rounders match, as the different skills needed would have been looked at and practised. I did not make any changes to my training programme during the course, although it would have been wise to have changed the chin-ups station in my fitness session as I did struggle with them. I was still able to do them, but I was unable to work flat-out for the whole required time. My heart rate was taken before I started, after the warm up and after every station. This helped me find out how hard I was working and whether over the course of the five weeks, I became fitter, resulting in a lower heart rate. My results show which stations I found easier and which I was best at performing. Final Evaluation  My post test score of the Illinois agility test was 20.37secs, but after my five week training programme, and having re-done the test, my time has improved to 19.18secs. It was an improvement of 1.19secs. Also, for my first abdominal curls test, I managed 82 sit-ups, but when I re-took it I was able to get up to 108, making an improvement of 26 sit-ups. This shows that my fitness level has increased form doing the five week training programme. My training programme was designed for one person during the fitness session and to work in pairs during the skills sessions. However, I had to work in a pair during the fitness session also as we had to time each other for each station. But this was not a problem as the rest gaps stayed constant, and it made it less complicated to do. All the equipment that was needed was available and there was not much setting up to do making it quick and easy to get on with. Overall, the programme was manageable and simple, as long as you are working in a pair. After completing the course, I find it a lot easier to complete each station with higher repetitions as my fitness level improved.  Although it was an exhausting and hard experience, I did enjoy it. I was able to increase my level of fitness, do a training programme that I designed and enjoyed and work with people that I got on with. This interaction did make it a lot more enjoyable. Out of the fitness stations, I enjoyed doing the sit-ups most, as I do these regularly and it is something I find easy and fun. However, I definitely liked the skills sessions best, as this put my rounders skills to the test and slowed me to play a part of a sport that I enjoy.  If I had to redo this in the future I would definitely change my chin-ups station in the fitness session as I found these hard and would probably have benefited a lot more with a different station.

Extracting DNA from Fruit in Various Stages of Ripeness

Extracting DNA from Fruit in Various Stages of Ripeness INTRODUCTION This life science based experiment will test strawberries in their various stages of ripeness, in order to see which stage will yield the most extractable DNA. An extraction kit will be designed from common household items, such as salt and detergent, in order to purify the DNA so that it is visible to the naked eye and can be weighed. Three degrees of strawberry will be tested: strawberries that have not fully ripened yet, identified by their firm bodies that are still a mixture of green and red; strawberries that have ripened fully, identified by their firm-but-not-hard bodies and bright red color; and strawberries that are overly ripe, which can be identified by their mushy and easily bruised bodies, as well as their dark red color. PROBLEM STATEMENT Which degree of strawberry ripeness will yield the most extractable DNA: under ripe, ripe, or over ripe? SUMMARY OF PROJECT PLAN First, the 1/2 teaspoon of salt, 1/3 cup of water, and 1 tablespoon of detergent needed for the DNA extraction liquid will be mixed and set aside. Three strawberries of the first stage of ripeness will be placed into a plastic bag and mashed into a pulp. Three tablespoons of the extraction liquid will be added to the bag and blended via the same mashing process. The strawberry mixture will then be poured into a nylon-covered funnel set over a small glass, until the liquid and pulp have been separated. One teaspoon of the strawberry mixtures liquid will then be poured into a test tube. 5 ml of chilled rubbing alcohol will be poured into the test tube after, so that it forms a layer atop the strawberry liquid. A droplet of blue dye will be added to the mix, so that it settles on the DNA between the layers and dyes it blue, making it easier to identify the DNA. The blue DNA will then be measured using milliliter markings on the test tube, and recorded. RELEVENCE Deoxyribonucleic Acid better known as DNA is a set of instructions that can be found in the cells of every living thing. The study of all DNA is very important. Without it, key medical discoveries that save countless lives every day would not be made. Using DNA, we are able to discover diseases a baby could inherit from its parents before birth, to detect whether a suspect is guilty or innocent, and to find chromosomal defects in patients with Downs Syndrome. The study of strawberry DNA specifically is also important, and can be applied to several real world scenarios. For instance, scientists are able to isolate particular proteins and chemicals that have been rumored to slow the spread of cancer. They are also able to clone proteins known for turning strawberries red and creating the strawberries flavor. The study of extractable strawberry DNA at various stages in maturation can also be applied to real world scenarios. Scientists are able to compare the growing process and maturation of strawberries to that of other fruits. It can also be used to advise consumers of when strawberries are at their peak, so that they are able to get the optimal amount of nutrients out of the fruit. A1. Literature Review Two studies were found that related specifically to this one. The first is an experiment conducted in 2009 by William S. Boyd. The second is another experiment conducted in 2005 by Kaeleigh Thorp. William S. Boyd Extracting DNA from Fruit in Stages of Ripeness SUMMARY The objective behind Boyds experiment was to find out whether ripe fruit would yield more extractable DNA than unripe or overripe. His experiment involved bananas, kiwis, and strawberries. The result was that, in the case of the kiwis and strawberries, ripe fruit did in fact yield more extractable DNA. However, he found that unripe bananas yield more extractable DNA than ripe and overripe. He concluded that, as fruit ripens, the nutrients break down and it begins to decompose, which destroys cells containing extractable DNA. CONNECTION As is the case with this experiment, Boyd wanted to know which stage of ripeness would yield the most DNA. COMPARING AND CONTRASTING Procedures Many of the procedures in Boyds experiment were similar yet different. Instead of putting the fruit in a bag and mashing it with his fingers, the fruit was blended in a food processor. The extraction liquid was chilled instead of the alcohol. The strawberry mixture was drained through nylon, but it was filtered and before being poured into the test tube instead of being filtered directly into the test tube. A graduated eyedropper was used to distribute the alcohol instead of pouring the alcohol down the side of the tube (Boyd, 2009). Materials Many of the materials in Boyds experiment were also similar. He used salt, water, and detergent to make his extraction liquid, which are the same materials as the extraction liquid in this study. He used alcohol to bring the DNA fibers together, blue dye to enhance the visibility and measurability of the extracted DNA, and a graduated test tube for measurements. However, there were some notable differences. He added pineapple juice to his extraction liquid, and his experiment used bananas and kiwis as well as strawberries, instead of strawberries alone (Boyd, 2009). Kaeleigh A. Thorp Extracting DNA from strawberries SUMMARY The objective behind Thorps experiment was to determine whether unripe, ripe, or overripe fruit would yield more extractable DNA. Her experiment used primarily strawberries. She hypothesized that ripe strawberries would yield the most extractable DNA, as under-ripe strawberries were not yet fully developed and overripe strawberries were too far into the decomposition process. Her findings supported her hypothesis, as the ripe strawberries did yield more extractable DNA (Thorp, 2007). CONNECTION Thorps experiment had the same objective as this study to find out what stage of ripeness would produce the most extractable DNA in Strawberries (Thorp, 2007). COMPARING AND CONTRASTING Procedures The procedures of Thorps experiment differed very little from this study. She chilled her extraction liquid by sitting it in a bowl of water and ice cubes, where this study did not require the extraction liquid be chilled. She used a blender to mash the fruit, instead of mashing it in a bag using fingers, and added water to it also something this study did not require. Lastly, again instead of using a plastic bag and fingers, she used a glass extraction rod to mix the extraction liquid with the blended strawberries (Thorp, 2007). Materials Thorp used nylon to filer the strawberry mixture, added blue dye to increase visibility and measurability, and used a graduated test tube for measurements, which are all in congruence with this study. However, instead of using salt, water, and detergent to make her own extraction liquid, Thorp used a premade Powdered Buffer made up of sodium chloride, sodium bicarbonate, and papain enzyme. She also used a premade Cell Blaster, containing sodium dodecyl sulfate (Thorp, 2007). A2a. Experimental Design Steps Preparation: Put the rubbing alcohol in a freezer or refrigerator, so that it will be cold enough to use later. Step 1: Extraction Liquid Combine a 1/2 teaspoon of salt, 1/3 cup of water, and 1 tablespoon of detergent in a jar to use as an extraction liquid. Mix it well and set it aside. Step 2: Prepare DNA for Extraction Take 3 strawberries and place it in a plastic bag. Push out all excess air and seal tightly. Mash the strawberry into a pulp by squeezing the bag with fingers. Do this for 2 minutes. Pour 3 tablespoons of the extraction liquid into the plastic bag. Push out all excess air and seal tightly. Mix the strawberry and extraction liquid by squeezing the bag with fingers. Do this for 1 minute. Step 3: Separate Liquid from Solid Stretch the nylon over the funnel. Place the tube of the funnel into a glass. Pour the strawberry pulp and extraction liquid over the nylon-lined funnel. Let the liquid drip into the glass for 30 seconds, or until the nylon stops dripping. Throw away the nylon and pulp. Step 4: Extract the DNA Pour the liquid into the test tube, filling it 1/4th of the way. Retrieve the rubbing alcohol from the freezer. Carefully tilting the test tube, pour the rubbing alcohol so that it runs slowly down the side instead of directly into the strawberry liquid and forms a layer on top of the strawberry liquid. Make sure the alcohol and the strawberry liquid do not mix, as the DNA collects between the layers. Add one drop of blue dye to the mixture. Take a moment to marvel at the blue gel-like substance (DNA made visible) that forms between the layers. Step 5: Measure Extracted DNA Using the graduated milliliter lines on the test tube, measure and record the amount of blue gel-like substance. Step 6: Repeat Process Thoroughly clean the cups, jar, test tube and funnel using water and paper towels. Repeat all of the steps with other strawberries, making sure to record the amount of DNA so a comparison can be made. A2b. Reasoning This method of experimental design was chosen because it called for fewer and more readily accessible supplies, and also because it had fewer and uncomplicated steps. The reasoning behind the method of testing this question was that overly complicated steps allow a higher margin for error. A simpler method provides fewer chances for mistakes to be made. There were several other studies consulted that had methods of testing similar to what is used in this experiment, but there were no other studies that had methods of testing that were the same. The method of testing in this experiment was developed using bits and pieces of other studies. The way this question is being tested is a better way than others because it was developed from bits and pieces of other more complicated studies, making it simpler. A2c. Sequence of Events The first step in collecting the data is adding one drop of blue dye to the layers of strawberry mixture and alcohol. The dye will collect between the layers and highlight the extracted DNA sitting in the middle, forming a blue gel-like substance. This gel-like substance will be measured and recorded using the millimeter markings on the graduated test tube. A2d. Tools Measuring cups Measuring spoons Small jar Graduated test tube Funnel Nylon Drinking Glass 9 Unripe strawberries 9 Ripe strawberries 9 Overripe strawberries 1/2 teaspoon of salt 1/3 cup of water 1 tablespoon of detergent 9 Resealing plastic bags 1 drop of blue dye A3. Variables A dependant variable is what the scientist measures, and is the part of the experiment that relies on changes made by the independent variable. An independent variable is what the scientist varies, and is the part of the experiment that decides the outcome of the dependant variable. A controlled variable is what the scientist keeps the same, and the part of the experiment that must not change in order to ensure that the results are measurable. DEPENDENT VARIABLE: Extracted DNA INDEPENDENT VARIABLE: Strawberries in three stages of development: under-ripe, ripe, and overripe CONTROLLED VARIABLE: The amount of strawberries, the amount of extraction liquid, the amount of alcohol, the amount of blue dye, the test tube and all other equipment. A4. Threat Reduction to Internal Validity Threats to the internal validity of this study have been reduced by the simple testable question, the properly identified variables, the control for outside influences, and the solid experimental procedure. MATURATION The experiment will be started and completed in a single day, and will take a maximum of two hours. That will allow sufficient time for each trial to be conducted carefully and for the utensils to be cleansed while assuring that there will be no time for the subjects to change before measurements. REPEATED MEASUREMENTS The experiment will be repeated three times for each type of strawberry, with a new set of materials each time, equating in exactly nine trial runs. Each sample will be disposed of after results are recorded, before the next trial was done none of the samples will be reused, nor will they come into contact with each other. INCONSISTENCE IN INSTRUMENTATIONÂ   In every trial run, the measurements will be taken using the same graduated test tube, glass, jar, and measuring spoons. Every measurement made will be taken in a way identical to the one before it, so that the outcome of the experiment is not compromised. EXPERIMENTAL MORTALITY The experiment is designed so that it cannot be completed without all of the subjects, meaning none of the subjects can drop out or be eliminated without completely derailing the study. This way, the trials will remain the same, and the results will not be compromised. EXPERIMENTER BIAS The experiment did not involve and could not come to any result that the experimenter would benefit directly from. The experimenter remained objective throughout the study. CONTROLLED VARIABLES There are several controlled variables that limit the factors that could skew the results. The tools for measurement remain the same throughout the trials so that there is no chance of new tools not providing the same results. The amount of strawberries stays the same three per trial so that the amount of extractable DNA is not distorted by one trial having more strawberries than the others. The amount of blue dye remains the same throughout the trials so that a larger amount of dye wont make the results seem bigger than they are. A5. Hypothesis: I predict that the ripe strawberries will produce more extractable DNA than both the under-ripe strawberries and the overripe strawberries. This prediction is based on observation. The under-ripe strawberry is still underdeveloped and very firm, meaning that it will likely produce less juice when mashed up less juice, less DNA. On the flipside, the overripe strawberry is overdeveloped and in a state of degradation, meaning that the DNA will likely be broken down and harder to extract. The ripe strawberry will produce more juice than the overripe, and will not be as susceptible to bruising and damage as the under-ripe, meaning it will likely produce more extractible DNA. B. Process of Data Collection The data was collected by first adding one drop of blue dye to the layers of strawberry mixture and alcohol in the graduated test tube. The dye gathered between the layers and around the extracted DNA that sat in the middle, so that it appeared to be a blue gel-like substance. This made the extracted DNA easier to see, which in turn made it easier to measure. The DNA was then measured and recorded using the millimeter markings on the graduated test tube. PROCESS OF RECORDING DATA: TOOLS USED FOR COLLECTION: 1 drop of blue dye Graduated test tube UNIT OF MEASUREMENT USED: Millimeter METHOD OF RECORDING: Unripe Ripe Over-Ripe Trial #1 3/4 ml 3 1/4 ml 1/2 ml Trial #2 1/2 ml 2 3/4 ml 1/4 ml Trial #3 1 ml 3 1/2 ml 1/2 ml B1. Appropriate Methods The methods described above were the best to conduct the experiment on this testable question because they relied less on scales. In many other studies, the ulterior way of measuring was to take a wooden rod, spool the DNA, and weigh it on a milligram scale. The wooden rod would be previously weighed and subtracted from the weight of the DNA spooled rod (science buddies). With the method used here, the rod is cut out of the picture only the DNA itself is measured. By doing this, we ensure that differently-weighted rods cannot skew the weight of the DNA. The drop of blue dye made it easier to see the extracted DNA. It was important that the DNA be clear so that the measurements were at their utmost accuracy. The graduated test tube made it so the DNA did not have to be spooled or moved before measuring, which kept the specimens together and limited the chances of losing or damaging the specimens. Millimeters were the practical unit of measurement, as the amount of extracted DNA is very small. C. Results The unripe strawberries were very firm and still mostly green. They were harder to mash up. The first trial including the unripe strawberries yielded 3/4 ml of extractable DNA. The second trial yielded less with 1/2 ml of extractable DNA. The third trial was the most successful, yielding 1 ml of extractable DNA. The ripe strawberries were softer and bright red all over. They were easier to mash. The first trial including the ripe strawberries yielded 3 1/4 ml of extractable DNA. The second trial yielded less with 2 3/4 ml of extractable DNA. The third trial once again was the most fruitful, yielding 3 1/2 ml. The over-ripe strawberries were very soft, a darker red, and covered in bruises. They were the easiest to mash up. The first trial including the over-ripe strawberries yielded 1/2 ml of extractable DNA. The second trial yielded a mere 1/4 ml of extractable DNA. The third trial produced the same results as the first, with 1/2 ml of extractable DNA. As the graph above shows, the ripe strawberries yielded a much larger amount than unripe and over-ripe strawberries. A single parallel is drawn between the unripe and over-ripe strawberries as they both yielded 1/2 ml of extractable DNA in separate trials unripe reaching 1/2 ml in Trial 2, over-ripe reaching 1/2 ml in trial 1. D. Conclusion The graph above displays how great the leap in extracted DNA was between the strawberry types. Although the unripe yielded higher results than the over-ripe strawberries in two of the trials (Trials #1 and #3), they both produced a minimal amount of extractable DNA when compared to the ripe strawberries. The unripe strawberries did not do as well because they are not yet mature. They provided less juice when mashed up for the extraction process, which provided fewer strands of DNA. The over-ripe strawberries did the worst because they are on the downgrade of maturation. While they provided plentiful juice for extraction, the DNA strands were destroyed in the process of decay. The ripe strawberries yielded the highest amounts of extractable DNA because they are at the hit the highest point of maturation. They provided the right amount of juice for the extraction process, and because they were at their peak, the DNA strands were intact. D1. Confirmation of Hypothesis I predicted that the ripe strawberries would produce more extractable DNA than both the under-ripe strawberries and the over-ripe strawberries. Based on my findings, with the ripe strawberries producing high amounts of extractable DNA where the unripe and over-ripe strawberries produced low amounts, it is evident that the ripe strawberries did yield the most extractable DNA. Therefore, I accept my initial hypothesis. D2. Experimental Design as Key Factor Experimental design is a key factor in science inquiry because it is the part in which groups are given their set treatments. In other words, experimental design is what decides if Group A will get Treatment B and Group C will get Treatment D, or if Group A will get Treatment D and Group C will get Treatment B. Without experimental design, the groups wont be assigned their proper treatments, and a statistical analysis cannot be made. If an experimental design is poorly constructed, it might miss some key components that affect the outcome altogether. For instance, if an experimental design lacks a control, nothing remains constant and some variables may not be counted for. Results of the experiment can be inconclusive, and when that happens, the study is rendered invalid. D3. Replication Replication is the process of repeating the steps of a procedure, so that an experiment can be duplicated again and again with the same results. Replication is important because there is always the possibility that results in a study have been skewed, or an experiment has been conducted wrong. Repeating the process and including several trials provides a way to prove that results are correct and to procure an average when averages are called for. This study is replicable because the instructions are clear and precise so that replication of the experiment as a whole is made easy, and the supplies needed are easy to find and easy to use. D3a. Evaluation of Validity Validity is important in science experiments because it proves the experiment was done correctly and the results were recorded accurately. Having a strong sense of validity means that the variables were measured reliably and strong causal links between the variables were found. REPLICATION This study is replicable in that there were three trials to each study. To confirm which one yielded more DNA than the rest, each type of strawberry was tested in three separate trials that way there were nine collective results each to consider instead of three. This study uses that replication to prove its analysis of the data. RELIABILITY This study is reliable thanks to that use of replication. Each type of strawberry was tested in three separate trials three for unripe, three for ripe, three for over-ripe to make sure the results were constant instead of a onetime occurrence. The results remained the in the same vicinity throughout the trials, proving that they are reliable. EXPERIMENTAL DESIGN The experimental design remains valid thanks to its simplicity. There was very little margin for error, and so repeating each trial using the same methods and measurements was quite simple. FUTURE QUESTIONS AND STUDIES Future studies might be expanded to use more than just strawberries. For example, one such study could compare ripe bananas to ripe strawberries, or ripe strawberries to ripe kiwis. Other studies might not involve strawberries at all, but replicate this study with a different fruit. For instance, would the results be the same with other fruits? Would ripe bananas yield more extracted DNA than unripe or overripe bananas?